[1] 国家自然科学基金面上项目,三维DNA纳米探针协同的肿瘤标志物联合检测SERS传感平台构建及性能研究,2019.01-2022.12,主持。
[2] 国家重点研发计划课题子课题,胃癌纳米检测器件与试剂盒的临床转化研究,2017.07-2022.06,主持。
[3] 国家自然科学基金青年项目,结合微流控和磁性分离技术的肺癌标志物SERS生物芯片研究,2014.01-2016.12,主持。
[4] 江苏省自然科学基金面上项目,靶向肿瘤细胞的集成SERS成像与光热-药物协同治疗功能的金纳米系统构建及性能研究,2018.07-2021.06,主持。
[5] 江苏省自然科学基金青年基金项目,高性能SERS探针的构建及其在肿瘤早期检测中的应用研究,2013.07-2016.06,主持。
[6] 应用光学国家重点实验室开放基金,面向肿瘤早筛与诊断的表面增强拉曼散射光学传感关键技术研究,2022.07-2024.06,主持。
[7] 江苏省高校自然科学研究重大项目,面肿瘤外泌体表面增强拉曼散射光学传感机理与技术研究, 2022.07-2024.06,主持。
[8] 国家重点研发计划项目,胃癌早期筛查与全病程监测的纳米技术及转化研究,2017.07-2022.06,参与。
[9] 教育部创新团队,有机与生物光电子学,2016.01-2018.12,参与。
[10] 国家重大科学研究计划项目(973项目),基于纳米技术的肺癌早期检测研究,2012.01-2016.08,参与。
(1)代表性学术论文
[1] Dong Chen, Fang Xinyue, Xiong Jingrong, Zhang Jingjing, Gan Hongyu, Song Chunyuan*, Wang Lianhui*. Simultaneous Visualization of Dual Intercellular Signal Transductions via SERS Imaging of Membrane Proteins Dimerization on Single Cells. ACS Nano, 2022, 16(9): 14055-14065.
[2] Liu Xinyu, Zhang Jingjing, Chen Zeyan, He Xiyu, Yan Chenlong, Lv Huiming, Chen Zhilong, Liu Ying*, Wang Lianhui*, Song Chunyuan*. Branched hybridization chain reaction and tetrahedral DNA-based trivalent aptamer powered SERS sensor for ultra-highly sensitive detection of cancer-derived exosomes[J]. Biosensors and Bioelectronics, 2025, 267: 116737.
[3] Zhang Jingjing, Chen Zhilong, Lv Huiming, Liang Jing, Yan Chenlong, Song Chunyuan*, Wang Lianhui*. Rapid and accurate SERS assay of disease-related nucleic acids based on isothermal cascade signal amplifications of CRISPR/Cas13a system and catalytic hairpin assembly[J]. Biosensors and Bioelectronics, 2024, 253: 116196.
[4] Gu Xinyue, Zhang Jingjing, Liang Jing, Liu Xinyu, He Xiyu, Jin Xiaoyuhao, Yan Chenlong, Wang Lianhui*, Song Chunyuan*. CRISPR/Cas13a Trans-Cleavage and Catalytic Hairpin Assembly Cascaded Signal Amplification Powered SERS Aptasensor for Ultrasensitive Detection of Gastric Cancer-Derived Exosomes[J]. Analytical Chemistry, 2024, 96(47): 18681-18689.
[5] Zhang Jingjing, Song Chunyuan*, Zhu Yunfeng, Gan Hongyu, Fang Xinyue, Peng Qian, Xiong Jingrong, Dong Chen, Han Caiqin*, Wang Lianhui*. A novel cascade signal amplification strategy integrating CRISPR/Cas13a and branched hybridization chain reaction for ultra-sensitive and specific SERS detection of disease-related nucleic acids. Biosensors and Bioelectronics, 2023, 219: 114836.
[6] Li Jinxiang#, Dong Chen#, Gan Hongyu, Gu Xinyue, Zhang Jingjing, Zhu Yunfeng, Xiong Jingrong, Song Chunyuan*, Wang Lianhui*. Nondestructive separation/enrichment and rolling circle amplification-powered sensitive SERS enumeration of circulating tumor cells via aptamer recognition. Biosensors & bioelectronics, 2023, 231: 115273-115273.
[7] Dong Chen, Xiong Jingrong, Ni Jie, Fang Xinyue, Zhang Jingjing, Zhu Dan, Weng Lixing, Zhang Yewei, Song Chunyuan*, Wang Lianhui*. Intracellular miRNA-Triggered Surface-Enhanced Raman Scattering Imaging and Dual Gene-Silencing Therapy of Cancer Cell. Analytical Chemistry, 2022, 94(26): 9336-9344.
[8] Zhang Jingjing, Miao Xiaping, Song Chunyuan*, Chen Na, Xiong Jingrong, Gan Hongyu, Ni Jie, Zhu Yunfeng, Cheng Kaiting*, Wang Lianhui*. Non-enzymatic signal amplification-powered point-of-care SERS sensor for rapid and ultra-sensitive assay of SARS-CoV-2 RNA. Biosensors and Bioelectronics, 2022, 212: 114379.
(2)专著
[1] 汪联辉,宋春元,吴江. 分子影像与精准诊断,上海:上海交通大学出版社,2020.
[2] 汪联辉,宋春元,张磊,朱丹. 纳米等离子激元材料及其生物医学应用,北京:科学出版社,2017.
(3)代表性专利
[1] 一种基于CRISPR/Cas13a系统的SERS检测试剂盒、其制备方法与应用,专利号:ZL202111590131.6,授权时间:2023.08.11
[2] 用于循环肿瘤细胞捕获、计数、无损释放的芯片及其应用,专利号:ZL202210541305.8,授权时间:2023.04.25
[3] 用于肿瘤蛋白和核酸标志物一体化检测的SERS传感器及其制备方法,专利号:ZL202010540034.5,授权时间:2022.09.27
[4] 一种癌症诊疗一体化纳米试剂及其制备方法和应用,专利号:ZL202210484991.X,授权时间:2022.05.06
[5] 膜蛋白二聚态原位检测试剂盒及其应用,专利号:ZL202210528479.0,授权日期:2022.07.29