樊春海简介
导师照片
性    别:
学    位: 博士学位
最高学历: 博士研究生
职   称: 研究员
职   务:
所在单位: 自动化学院实验教学中心
导师类别: 兼职博士生导师
招生学科: 0803光学工程080300光学工程085202光学工程

个人简介 

在南京大学获得生物化学学士(1996年)和博士(2000年)学位,后在加州大学圣巴巴拉分校有机固体研究所和加州纳米系统研究所Alan J. Heeger(2000年诺贝尔化学奖得主)实验室从事博士后研究。2004年1月起任中国科学院上海应用物理研究所研究员、博士生导师,现任物理生物学研究室主任。2004年入选中国科学院百人计划(终期评估优秀),2007年国家杰出青年基金获得者,2011年任科技部973首席科学家。

研究方向及主要成果 

研究方向
主要研究方向为生物传感器、DNA纳米技术和生物光子学。已在Nature Nanotechnology, Nature Protocols, PNAS, JACS, Angew. Chem, Adv. Mater.等杂志发表论文180余篇(其中60余篇影响因子>7), 论文引用近5000次(12篇>100次)。多篇论文在JACS,Angew. Chem.,Adv. Mater.,Small,Chem. Commun.等杂志以封面论文形式发表,并为Nature杂志highlight,Nature China,Chemical & Engineering News,MRS Bulletin等科学媒体报道。应邀在Account of Chemical Research,Chemical Society Reviews,Trends in Biotechnology,Trends in Analytical Chemistry与Pure and Applied Chemistry等权威杂志撰写研究综述。已申请八项美国、国际专利和二十余项中国专利。
主要荣誉:
主要获得荣誉包括国家杰出青年基金(2007)、 中国青年科技奖(2011)、中国化学会青年化学奖(2006)、中国分析测试协会科学技术奖一等奖(2007-2009)、中国科学院优秀研究生指导教师奖、上海市优秀学科带头人等。指导研究生获得全国优秀博士论文提名奖(2009,2011)、中科院(2008, 2010)和上海市(2008)优秀博士论文等荣誉。
主持科研项目:
主持科研项目包括国家重大科技专项、973、863重点、基金委重大研究计划、中科院重要方向性项目等。其中近5年的主要项目包括:
1) 国家重大科学研究计划,人工纳米生物机器构筑与生物医学应用的基础研究2007CB936000(课题组长),2007.8-2011.12
2) 国家杰出青年基金“电化学分析”20725516,2008.1-2011.12,200万
3) 国家自然科学基金(面上),“核酸探针的界面自组装过程及电化学DNA生物传感器的研究”(20873175),2009.1-2011.12(项目负责人)36万
4) 上海纳米专项,“量子点蛋白质芯片在基于唾液的肿瘤快速检测中的应用”0952nm04600,2009.7.1-2011.6.30(项目负责人), 70万
5) 国家自然科学基金(重大研究计划),“化学小分子调控的肿瘤抑癌基因甲基化信号转导过程的生物检测方法研究”(90913014), 2010.1-2012.12(项目负责人),130万
6) 国家传染病重大科技专项,“若干生物传感器与芯片技术研究及其在重大传染病快速检测中的应用”(2009ZX10004-301) 2009.1-2010.12(课题负责人)704万
7) 科技部重大科学研究计划,“纳米界面生物分子作用机制的基础研究及其在前列腺癌早期检测中的应用”(2012CB932600), 2012.1-2016.12(首席科学家)2900万。

主要学术论文:
近5年(2007-2012)已发表SCI论文100余篇,其中影响因子>7(通讯作者或共同通讯作者)论文列表如下:
1. Wei, M., Chen, H., Li, J., Yin, M., Liang, L., He, Y., Song, H., Fan, C. and Huang, Q. (2011) Polyvalent immunostimulatory nanoagents with self-assembled CpG oligonucleotide-conjugated gold nanoparticles. Angew. Chem. Int. Ed., 51, 1202-1206.
2. Chen, N., He, Y., Su, Y., Li, X., Huang, Q., Wang, H., Zhang, X., Tai, R. and Fan, C. (2012) The cytotoxicity of cadmium-based quantum dots. Biomaterials, 33, 1238-11244.
3. Chen, P., Pan, D., Fan, C., Chen, J., Huang, K., Wang, D., Zhang, H., Li, Y., Feng, G., Liang, P., He, L. and Shi, Y. (2011) Gold nanoparticles for high-throughput genotyping of long-range haplotypes. Nature Nanotechnol., 6, 639-644.
4. Zheng, X., Liu, Q., Jing, C., Li, Y., Li, D., Luo, W., Wen, Y., He, Y., Huang, Q., Long, Y. and Fan, C. (2011) Catalytic Gold Nanoparticles for Nanoplasmonic Detection of DNA Hybridization. Angew. Chem. Int. Ed., 50, 11994-11998.
5. He, Y., Zhong, Y., Su, Y., Lu, Y., Jiang, Z., Peng, F., Xu, T., Su, S., Huang, Q., Fan, C. and Lee, S.-T. (2011) Water-Dispersed Near-Infrared-Emitting Quantum Dots of Ultrasmall Sizes for In Vitro and In Vivo Imaging. Angew. Chem. Int. Ed., 50, 5695-5698.
6. Gao, A., Lu, N., Dai, P., Li, T., Pei, H., Gao, X., Gong, Y., Wang, Y. and Fan, C. (2011) Silicon-Nanowire-Based CMOS-Compatible Field-Effect Transistor Nanosensors for Ultrasensitive Electrical Detection of Nucleic Acids. Nano Lett., 11, 3974-3978.
7. Wang, L., Pu, K., Li, J., Qi, X., Li, H., Zhang, H., Fan, C. and Liu, B. (2011) A Graphene/Conjugated Oligomer Hybrid Probe for Light-up Sensing of Lectin and Escherichia coli. Adv. Mater., 23, 4386-4391.
8. He, Y., Su, S., Xu, T., Zhong, Y., Zapien, A., Li, J., Fan, C. and Lee, S.-T. (2011) Silicon Nanowires-Based Highly-Efficient SERS-Active Platform for Ultrasensitive DNA Detection. Nano Today, 6, 122-130.
9. Peng, C., Jiang, B., Liu, Q., Guo, Z., Xu, Z., Huang, Q., Xu, H., Tai, R. and Fan, C. (2011) Graphene-templated formation of two-dimensional lepidocrocite nanostructures for high-efficiency catalytic degradation of phenols. Energy Environ. Sci., 4, 2035-2040.
10. Li, J., Pei, H., Zhu, B., Liang, L., Wei, M., He, Y., Chen, N., Li, D., Huang, Q. and Fan, C. (2011) Self-Assembled Multivalent DNA Nanostructures for Noninvasive Intracellular Delivery of Immunostimulatory CpG Oligonucleotides. ACS Nano, 5, 8783-8789.
11. Hu, W., Peng, C., Lv, M., Li, X., Zhang, Y., Chen, N., Fan, C. and Huang, Q. (2011) Protein Corona-Mediated Mitigation on Cytotoxicity of Graphene Oxide. ACS Nano, 5, 5, 3693-3670.
12. Su, Y., Peng, F., Jiang, Z., Zhong, Y., Lu, Y., Jiang, X., Huang, Q., Fan, C., Lee, S.-T. and He, Y. (2011) In vivo distribution, pharmacokinetics, and toxicity of aqueous synthesized cadmium-containing quantum dots. Biomaterials, 32, 5855-5862.
13. He, Y., Lu, H., Su, Y., Sai, L., Hu, M., Fan, C. and Wang, L. (2011) Ultra-photostable, non-cytotoxic, and highly fluorescent quantum nanospheres for long-term, high-specificity cell imaging. Biomaterials, 32, 2133-2140.
14. Li, D., Song, S. and Fan, C. (2010) Target-responsive structures for nucleic acid sensors. Acc. Chem. Res., 43, 631-641.
15. Song, S., Qin, Y., He, Y., Huang, Q., Fan, C. and Chen, H. (2010) Functional nanoprobes for ultrasensitive detection of biomolecules. Chem. Soc. Rev., 39, 4234-4243.
16. He, Y., Fan, C. and Lee, S.-T. (2010) Silicon nanostructures for bioapplications. Nano Today, 5, 282-295.
17. Luo, C., Zheng, H., Wang, L., Fang, H., Hu, J., Fan, C., Cao, Y. and Wang, J. (2010) Direct 3D Imaging of the Buried Interfaces between Water and Superhydrophobic Surfaces. Angew. Chem. Int. Ed., 49, 9145-9148 (Featured in Nature China).
18. Yang, Y., Liu, G., Liu, H., Li, D., Fan, C. and Liu, D. (2010) An electrochemically actuated reversible DNA switch. Nano Lett., 10, 1393-1397 (Featured in Nature China).
19. Liu, G., Sun, C., Li, D., Song, S., Mao, B., Fan, C. and Tian, Z. (2010) Gating of redox currents at gold nanoelectrodes via DNA hybridization. Adv. Mater., 22, 2148-2150.
20. Zhang, Z., Wang, Y., Fan, C., Li, C., Li, Y., Qian, L., Fu, Y., Shi, Y., Hu, J. and He, L. (2010) Asymmetric DNA origami for spatially addressable and index-free solution-phase DNA chips. Adv. Mater., 22, 2672-2675.
21. Lv, M., Su, S., He, Y., Huang, Q., Hu, W., Li, D., Fan, C. and Lee, S.-T. (2010) Long-term antimicrobial effect of silicon nanowires decorated with silver nanoparticles. Adv. Mater., 22, 5463-5467.
22. Pei, H., Lu, N., Wen, Y., Song, S., Liu, Y., Yan, H. and Fan, C. (2010) A DNA Nanostructure-based Biomolecular Probe Carrier Platform for Electrochemical Biosensing. Adv. Mater., 22, 4754-4758.
23. Hu, W., Peng, C., Luo, W., Lv, M., Li, X., Li, D., Huang, Q. and Fan, C. (2010) Graphene-based antibacterial paper. ACS Nano, 4, 4317-4323.
24. Hu, M., Yan, J., He, Y., Lu, H., Weng, L., Song, S., Fan, C. and Wang, L. (2010) Ultrasensitive, multiplexed detection of cancer biomarkers directly in serum by using a quantum dot based microfluidic protein chip. ACS Nano, 4, 488-494.
25. Luo, W., Zhu, C., Su, S., Li, D., He, Y., Huang, Q. and Fan, C. (2010) Self-catalyzed, Self-limiting Growth of Glucose Oxidase-Mimicking Gold Nanoparticles. ACS Nano, 4, 7451-7458.
26. Zhou, Y., Huang, Q., Gao, J., Lu, J., Shen, X. and Fan, C. (2010) A dumbbell probe-mediated rolling circle amplification strategy for highly sensitive microRNA detection. Nucleic Acids Res., 38, e156.
27. Su, Y., Hu, M., Fan, C., He, Y., Li, Q., Li, W., Wang, L., Shen, P. and Huang, Q. (2010) The cytotoxicity of CdTe quantum dots and the relative contributions from released cadmium ions and nanoparticle properties. Biomaterials, 31, 4829-4834.
28. Li, J., Zhu, Y., Li, W., Zhang, X., Peng, Y., Huang, Q. (2010) Nanodiamonds as intracellular transporters of chemotherapeutic drug. Biomaterials, 31, 8410-8418
29. He, Y., Lu, H., Su, Y., Sai, L., Hu, M., Fan, C. and Wang, L. (2010) Ultra-photostable, Non-cytotoxic, and Highly Fluorescent Quantum Nanospheres for Long-Term, High-Specificity Cell Imaging. Biomaterials, 32, 2133-2140.
30. He, S., Song, B., Li, D., Zhu, C., Qi, W., Wen, Y., Wang, L., Song, S., Fang, H. and Fan, C. (2010) A graphene nanoprobe for rapid, sensitive and multicolor fluorescent DNA analysis. Adv. Funct. Mater., 20, 453-459.
31. Zhang, J., Wang, L., H. Zhang, Boey, F., Song, S. and Fan, C. (2010) Aptamer-based multicolor fluorescent gold nanoprobes for multiplex detection in homogeneous solution. Small, 6, 201-204.
32. Peng, C., Hu, W., Zhou, Y., Fan, C. and Huang, Q. (2010) Intracellular imaging with a graphene-based fluorescent probe. Small, 6, 1686-1692.
33. Zhang, Z., Zeng, D., Ma, H., Feng, G., Hu, J., He, L., Li, C. and Fan, C. (2010) A DNA-Origami Chip Platform for Label-Free SNP Genotyping Using Toehold-Mediated Strand Displacement. Small, 6, 1854-1858 (Frontispiece paper).
34. Yan, J., Song, S., Li, B., Huang, Q., Zhang, Q., Zhang, H. and Fan, C. (2010) An on-nanoparticle rolling circle amplification platform for ultrasensitive protein detection in biological fluids. Small, 6, 2520-2525.
35. Song, S., Liang, Z., Zhang, J., Wang, L., Li, G. and Fan, C. (2009) Gold-Nanoparticle-Based Multicolor Nanobeacons for Sequence-Specific DNA Analysis. Angew. Chem. Int. Ed., 48, 8670-8674. (Frontpiece paper & Featured in Nature China)
36. He, Y., Kang, Z., Li, Q., Tsang, C.H.A., Fan, C. and Lee, S.-T. (2009) Ultrastable, Highly Fluorescent, and Water-Dispersed Silicon-Based Nanospheres as Cellular Probes. Angew. Chem. Int. Ed., 48, 128-132.
37. He, Y., Su, Y., Yang, X., Kang, Z., Xu, T., Zhang, R., Fan, C. and Lee, S.-T. (2009) Photo and pH Stable, Highly-Luminescent Silicon Nanospheres and Their Bioconjugates for Immunofluorescent Cell Imaging. J. Am. Chem. Soc., 131, 4434-4438.
38. Mi, L., Wen, Y., Pan, D., Wang, Y., Fan, C. and Hu, J. (2009) Modulation of DNA Polymerases with Gold Nanoparticles and their Applications in Hot-Start PCR. Small, 5, 2597-2600.
39. Luo, C., Zuo, X., Wang, L., Wang, E., Song, S., Wang, J., Wang, J., Fan, C. and Cao, Y. (2008) Flexible Carbon Nanotube-Polymer Composite Films with High Conductivity and Superhydrophobicity Made by Solution Process. Nano Lett., 8, 4454-4458.
40. Liu, G., Wan, Y., Gau, V., Zhang, J., Wang, L., Song, S. and Fan, C. (2008) An enzyme-based E-DNA sensor for sequence-specific detection of femtomolar DNA targets. J. Am. Chem. Soc., 130, 6820-6825.
41. Li, J., Song, S., Liu, X., wang, L., Pan, D., Huang, Q., Zhao, Y. and Fan, C. (2008) Enzyme-based multi-component optical nanoprobes for sequence-specific detection of DNA hybridization. Adv. Mater., 20, 479-500.
42. Zhang, J., Wang, L., Pan, D., Song, S., Boyer, F.Y., Zhang, H. and Fan, C. (2008) Visual Cocaine Detection with Gold Nanoparticles and Rationally Engineered Aptamer Structures. Small, 4, 1196-1200.
43. Song, S., Wang, L., Li, J., Zhao, J. and Fan, C. (2008) Aptamer-based biosensors. Trends Anal. Chem., 27, 108-117.
44. Zhang, J., Song, S., Wang, L., Pan, D. and Fan, C. (2007) A gold nanoparticle-based chronocoulometric DNA sensor for amplified detection of DNA. Nature Protocols, 2, 2888-2895.
45. Wang, J., Wang, L., Liu, X., Liang, Z., Song, S., Li, W., Li, G. and Fan, C. (2007) A gold nanoparticle-based aptamer target binding readout for ATP assay. Adv. Mater., 19, 3943-3946.
46. Zuo, X., Song, S., Zhang, J., Pan, D., Wang, L. and Fan, C. (2007) A target-responsive electrochemical aptamer switch (TREAS) for reagentless detection of nanomolar ATP. J. Am. Chem. Soc., 129, 1042-1043.
47. Liu, X., Tang, Y., Wang, L., Zhang, J., Song, S., Fan, C. and Wang, S. (2007) Optical detection of mercury (II) in aqueous solutions using conjugated polymers and label-free oligonucleotides. Adv. Mater., 19, 1471-1474.

联系方式 

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Email   :iamchfan@njupt.edu.cn

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